Research Engineer / Assistant Research Engineer- Preclinical Sarcoma Models (F/M) (F/H)
75005, Paris, France
Environnement et contexte de travail
Notre établissement fait partie de l'Université PSL. Située au cœur de Paris, celle-ci fait dialoguer tous les domaines du savoir, de l'innovation et de la création. Classée parmi les 50 premières universités mondiales, elle forme au plus près de la recherche des chercheurs, artistes, ingénieurs, entrepreneurs ou dirigeants conscients de leur responsabilité sociale, individuelle et collective.
Structure d'accueil
The Curie Institute Research Center
France’s leading cancer research and treatment centre, Institut Curie unites a renowned research centre and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.
Missions
Activités principales
Laboratory
The RACER (Rare Cancers Exploration and Research) team, led by Dr. Sarah Watson within the Chemical Biology of Cancers Unit (INSERM U1339, CNRS UMR366), conducts translational research focused on rare cancers, particularly cancers of unknown primary (CUP) and soft tissue sarcomas. The team integrates genomic and transcriptomic approaches, including single-cell analyses, with innovative preclinical models and direct access to patient cohorts and biological samples from Institut Curie.
This position aims to support and expand the team's preclinical modeling activities, including cell lines, 3D cultures, organoids, and PDX. These models are central to therapeutic target validation and drug screening projects in sarcoma research. The successful candidate will work under the direct supervision of Dr. Watson and interact closely with researchers and technological platforms at Institut Curie.
Missions
Development and Characterization of Models
- Establish and characterize sarcoma-derived cell lines, organoids, and PDX models from patient samples
- Develop and optimize 3D culture systems and co-cultures with stromal or immune cells
- Contribute to the maintenance, monitoring, and annotation of models and associated biobanks
- Perform functional assays, including viability, dose-response, and drug screening studies
Molecular and Cellular Characterization
- Extract nucleic acids and proteins and perform quality assessment
- Prepare sequencing samples and/or libraries and liaise with sequencing platforms
- Conduct standard molecular and cellular biology techniques, including RT-qPCR, Western blotting, flow cytometry, immunofluorescence, and immunohistochemistry
- Perform genetic engineering using transfection, lentiviral transduction, and CRISPR/Cas9
- Contribute to quality control and preliminary data analysis
Laboratory Organization and Scientific Contributions
- Ensure experimental traceability, data management, and regulatory compliance
- Participate in laboratory operations, including inventory management, purchasing, and equipment maintenance
- Train and support students and new team members in cell culture and preclinical modeling techniques
- Present research findings and contribute to publications, grant reports, and regulatory documentation
Constraints and risks
Work in a Biosafety Level 2 (BSL-2) laboratory handling human samples
Occasional schedule flexibility required to accommodate cell culture experiments, in vivo studies, and receipt of clinical specimens.
Profil du candidat
Savoirs et compétences attendus
Training and experience required
- Education and qualifications: Professional Bachelor's degree or University Bachelor of Technology (BUT) in Biology, Biotechnology, or Biological Sciences for an Assistant Research Engineer position; Master's degree (MSc) or Engineering degree in Cell Biology, Molecular Biology, Oncology, or Biotechnology for a Research Engineer position.
- Professional experience: 2 to 5 years of experience with a focus on the development of cellular and/or animal models in oncology.
- Certifications in laboratory animal science (designer or operator level) and authorization to work with Class 2 genetically modified organisms (GMOs) is an asset.
- Required expertise: Hands-on experience with established and primary cell culture, 3D culture systems and organoids, molecular biology techniques and NGS library preparation, cellular imaging, and flow cytometry. A solid understanding of tumor biology is expected. Experience with sarcomas or other mesenchymal tumors would be advantageous but is not required.
Skills required
- Language skills: Fluent French and scientific English
- Computing skills: Proficiency with standard office software, electronic laboratory notebooks (ELNs), and data analysis/quantification tools such as GraphPad Prism, FlowJo, and ImageJ/Fiji. Basic knowledge of R or Python for the exploration and analysis of sequencing data would be an asset.
- Personal skills: Strong experimental rigor and attention to traceability, ability to work independently and manage experiments autonomously, strong organizational skills with the capacity to handle multiple projects simultaneously and meet deadlines, enthusiasm for multidisciplinary teamwork involving clinicians, biologists, and bioinformaticians.
Contract information
Type of contract: Fixed-term contract
Starting date: as soon as possible
Duration: 2 years, renewable
Working time: full time 39 hours per week
Annual Gross Salary: from 27504€ to 31735€ according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Contact
Please send your CV, letter of motivation and 2 references
Publication date: 16/10/2026
Deadline for application: to be completed
Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.All our opportunities are open to people with disabilities
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
Diplôme et expérience professionnelle
Bac+3, Bac+5Non discrimination, ouverture et transparence
Notre établissement, comme l'ensemble de l'Université PSL, s’engage à soutenir et promouvoir l’égalité, la diversité et l’inclusion au sein de ses communautés. Nous encourageons les candidatures issues de profils variés, que nous veillerons à sélectionner via un processus de recrutement ouvert et transparent.
Contact
55sst0l7v25k@emploi.beetween.com
Autres informations
Research Engineer / Assistant Research Engineer- Preclinical Sarcoma Models (F/M) (F/H)
| Localisation du poste 75005, Paris, France |
|---|
| Établissement Institut Curie |
Environnement et contexte de travail
Notre établissement fait partie de l'Université PSL. Située au cœur de Paris, celle-ci fait dialoguer tous les domaines du savoir, de l'innovation et de la création. Classée parmi les 50 premières universités mondiales, elle forme au plus près de la recherche des chercheurs, artistes, ingénieurs, entrepreneurs ou dirigeants conscients de leur responsabilité sociale, individuelle et collective.
Structure d'accueil
The Curie Institute Research Center
France’s leading cancer research and treatment centre, Institut Curie unites a renowned research centre and a specialist hospital, fostering close collaboration between scientists, clinicians and healthcare professionals. It offers an environment of excellence where expertise comes together around shared values: care, humanity, openness, collaboration, efficiency, innovation, solidarity and commitment.
Missions
Activités principales
Laboratory
The RACER (Rare Cancers Exploration and Research) team, led by Dr. Sarah Watson within the Chemical Biology of Cancers Unit (INSERM U1339, CNRS UMR366), conducts translational research focused on rare cancers, particularly cancers of unknown primary (CUP) and soft tissue sarcomas. The team integrates genomic and transcriptomic approaches, including single-cell analyses, with innovative preclinical models and direct access to patient cohorts and biological samples from Institut Curie.
This position aims to support and expand the team's preclinical modeling activities, including cell lines, 3D cultures, organoids, and PDX. These models are central to therapeutic target validation and drug screening projects in sarcoma research. The successful candidate will work under the direct supervision of Dr. Watson and interact closely with researchers and technological platforms at Institut Curie.
Missions
Development and Characterization of Models
- Establish and characterize sarcoma-derived cell lines, organoids, and PDX models from patient samples
- Develop and optimize 3D culture systems and co-cultures with stromal or immune cells
- Contribute to the maintenance, monitoring, and annotation of models and associated biobanks
- Perform functional assays, including viability, dose-response, and drug screening studies
Molecular and Cellular Characterization
- Extract nucleic acids and proteins and perform quality assessment
- Prepare sequencing samples and/or libraries and liaise with sequencing platforms
- Conduct standard molecular and cellular biology techniques, including RT-qPCR, Western blotting, flow cytometry, immunofluorescence, and immunohistochemistry
- Perform genetic engineering using transfection, lentiviral transduction, and CRISPR/Cas9
- Contribute to quality control and preliminary data analysis
Laboratory Organization and Scientific Contributions
- Ensure experimental traceability, data management, and regulatory compliance
- Participate in laboratory operations, including inventory management, purchasing, and equipment maintenance
- Train and support students and new team members in cell culture and preclinical modeling techniques
- Present research findings and contribute to publications, grant reports, and regulatory documentation
Constraints and risks
Work in a Biosafety Level 2 (BSL-2) laboratory handling human samples
Occasional schedule flexibility required to accommodate cell culture experiments, in vivo studies, and receipt of clinical specimens.
Profil du candidat
Savoirs et compétences attendus
Training and experience required
- Education and qualifications: Professional Bachelor's degree or University Bachelor of Technology (BUT) in Biology, Biotechnology, or Biological Sciences for an Assistant Research Engineer position; Master's degree (MSc) or Engineering degree in Cell Biology, Molecular Biology, Oncology, or Biotechnology for a Research Engineer position.
- Professional experience: 2 to 5 years of experience with a focus on the development of cellular and/or animal models in oncology.
- Certifications in laboratory animal science (designer or operator level) and authorization to work with Class 2 genetically modified organisms (GMOs) is an asset.
- Required expertise: Hands-on experience with established and primary cell culture, 3D culture systems and organoids, molecular biology techniques and NGS library preparation, cellular imaging, and flow cytometry. A solid understanding of tumor biology is expected. Experience with sarcomas or other mesenchymal tumors would be advantageous but is not required.
Skills required
- Language skills: Fluent French and scientific English
- Computing skills: Proficiency with standard office software, electronic laboratory notebooks (ELNs), and data analysis/quantification tools such as GraphPad Prism, FlowJo, and ImageJ/Fiji. Basic knowledge of R or Python for the exploration and analysis of sequencing data would be an asset.
- Personal skills: Strong experimental rigor and attention to traceability, ability to work independently and manage experiments autonomously, strong organizational skills with the capacity to handle multiple projects simultaneously and meet deadlines, enthusiasm for multidisciplinary teamwork involving clinicians, biologists, and bioinformaticians.
Contract information
Type of contract: Fixed-term contract
Starting date: as soon as possible
Duration: 2 years, renewable
Working time: full time 39 hours per week
Annual Gross Salary: from 27504€ to 31735€ according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Contact
Please send your CV, letter of motivation and 2 references
Publication date: 16/10/2026
Deadline for application: to be completed
Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.All our opportunities are open to people with disabilities
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
Diplôme et expérience professionnelle
Bac+3, Bac+5Non discrimination, ouverture et transparence
Notre établissement, comme l'ensemble de l'Université PSL, s’engage à soutenir et promouvoir l’égalité, la diversité et l’inclusion au sein de ses communautés. Nous encourageons les candidatures issues de profils variés, que nous veillerons à sélectionner via un processus de recrutement ouvert et transparent.
Contact
55sst0l7v25k@emploi.beetween.com
Autres informations
| Référence 55sst0l7v2 |
|---|
L'Université PSL (Paris Sciences & Lettres)
